Bart De Taeye, PhD
Research Assistant Professor

Bart De Taeye graduated as a Pharmacist at the Katholieke Universiteit of Leuven, Belgium. He went on to obtain his PhD degree in Pharmaceutical Sciences at the Katholieke Universiteit of Leuven. During this period he also earned a Postgraduate degree in Business Economics at the Graduate School of Business Studies at the Katholieke Universiteit of Leuven. Bart completed his postdoctoral research training in the Division of Cardiology at Vanderbilt University from 2004 – 2007. In 2007 he became a faculty member at Vanderbilt University before joining Northwestern’s faculty in August 2008.

Bart’s research focuses on the role of Plasminogen Activator Inhibitor-1 in the development of obesity and diabetes.  In addition, he investigates the role of Soluble Epoxide Hydrolase in the metabolic syndrome.

He is a member of the North American Association for the Study of Obesity, The American Diabetes Association, The American Heart Association, The International Society for Fibrinolysis and Proteolysis and the International Society of Thrombosis and Haemostasis.

Selected Publications

De Taeye, B.; Novitskaya, T.; McGuinness, P.; Gleaves, L.; Mousumi, M.; Covington, J.; Vaughan, D.E.  Macrophage TNF-α contributes to insulin resistance and hepatic steatosis in diet-induced obesity.  Am. J. Physiol. Endocrinol. Metab. 2007, 293 (3), E713-725.

De Taeye, B.; Novitskaya, T.; Gleaves, L.; Covington, J.; Vaughan, D.E.  Bone Marrow Plasminogen Activator Inhibitor-1 Influences the Development of Obesity.  J. Biol. Chem. 2006, 281, 32796-32805.

De Taeye, B.; Gils, A.; Vleugels, N.; Rabijns, A.; Declerck, P.J.  Comparative analysis of the proteinase specificity in wild-type and stabilized plasminogen activator inhibitor-1: evidence for contribution of intramolecular flexibility.  Biochem. Biophys. Res. Comm. 2004, 321, 746-751.

De Taeye, B.; Compernolle, G.; Declerck, P.J.  Site-directed targeting of plasminogen activator inhibitor-1 as an example for a novel approach in rational drug design.  J. Biol. Chem. 2004, 279 (19), 20447-20450.

De Taeye, B.; Verbeke, K.; Compernolle, G.; Biesemans, W.; Gils, A.; Declerck, P.J.  Structural determinants in the stability of the serpin/proteinase complex.  Biochem. Biophys. Res. Comm. 2003, 307, 529-534.

De Taeye, B.; Compernolle, G.; Dewilde, M.; Biesemans, W.; Declerck, P.J.  Immobilization of the distal hinge in the labile serpin PAI-1: Identification of a transition state with distinct conformational and functional properties.  J. Biol. Chem. 2003, 278 (26), 23899-23905.