Raj Kishore, PhD
Assistant Professor of Medicine

Raj Kishore earned a BS degree in biosciences and an MS degree in human biology and anthropology at the University of Lucknow in India. He earned his PhD degree in immunology and medical genetics at the University of Lucknow and SG Postgraduate Institute of Medical Sciences in India. Dr. Kishore completed postdoctoral training at the Departments of Immunology at New York Medical College, from 1996 –98, and the Lerner Research Institute, Cleveland Clinic Foundation, from 1998- 2000. He received additional training at the Department of Nutrition, Case Western Reserve University, Cleveland, 2000–01.

He served on the faculty of Tufts University in Boston from October 2001 until he joined Northwestern in February 2007.

Dr. Kishore's research interests include the differentiation of embryonic and adult stem cells in cardiovascular repair and regeneration; mechanisms of somatic cell de-differentiation and epigenetic nuclear reprogramming; stimulus-induced endothelial cell biology and dysfunction; post-transcriptional and post-translational mechanisms of inflammatory gene regulation and cytokine biology; antigen presentation and processing in cancers; signal transduction; and the mechanisms and pathophysiology of chronic alcohol-mediated organ damage.

He is a member of the Indian Immunology Society, the American Association of Immunologists, the American Heart Association, the American Stroke Association, and the Research Society on Alcoholism.

Selected Recent Publications

Losordo, D.W.; Kishore, R.  A Big Promise from the Very Small: Identification of Circulating ES-like Pluripotent Cells in Patients with Acute Myocardial Infarction (editorial).  J. Am. Coll. Cardiol. 2009, 53(1), 10-12.

Krishnamurthy, P.; Lambers, E.; Johnson, R.; Qin, G.; Losordo, D.W.; Kishore, R. IL-10 inhibits inflammation mediated cardiac dysfunction after myocardial infarction.  Circ. Res. 2008, Dec 18. [Epub ahead of print]

Suriano, R.; Chaudhuri, D.; Johnson, R.S. ; Lambers, E. ; Ashok, B.T.; Kishore, R.; Tiwari, R.K. 17Beta-estradiol mobilizes bone marrow-derived endothelial progenitor cells to tumors.  Cancer Res. 2008, 68(15), 6038-6042.

Rajasingh, J.; Lambers, E.; Hamada, H.; Bord, E.; Thorne, T.; Goukassian, I.; Krishnamurthy, P.; Rosen, K.M.; Ahluwalia, D.; Zhu, Y.; Qin, G.; Losordo, D.W.; Kishore, R.  Cell-Free Embryonic Stem Cell Extract-Mediated Derivation of Multipotent Stem Cells From NIH3T3 Fibroblasts for Functional and Anatomical Ischemic Tissue Repair.  Circ. Res. 2008, 102(11), e107-17.

Rajasingh, J.; Bord, E.; Hamada, H.; Lambers, E.; Qin, G.; Losordo, D.W.; Kishore, R.  STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction.  Circ. Res. 2007, 101(9), 910-918.

Rajasingh, J.; Bord, E.; Qin, G.; Ii, M.; Silver, M.; Hamada, H.; Ahluwalia, D.; Goukassian, D.; Zhu, Y.; Losordo, D.W.; Kishore, R.;  Enhanced voluntary alcohol consumption after estrogen supplementation negates estrogen-mediated vascular repair in ovariectomized mice.  Endocrinology 2007, 14(8), 3618-3624.

Goukassian, D.A.; Qin, G.; Dolan, C.; Murayama, T.; Silver, M.; Curry, C.; Eaton, E.; Luedemann, C.; Ma, H.; Asahara, T.; Zak, V.; Mehta, S.; Burg, A.; Thorne, T.; Kishore, R.; Losordo, D.W.  Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization.  Circulation 2007, 115(6), 752-62.

Kishore, R.; Losordo, D.W.  Gene therapy for restenosis: biological solution to a biological problem.  J. Mol. Cell Cardiol. 2007, 42(3), 461-468.

Hamada, H.; Kim, M.K.; Iwakura, A.; Ii, M.; Thorne, T.; Qin, G.; Asai, J.; Tsutsumi, Y.; Sekiguchi, H.; Silver, M.; Wecker, A.; Bord, E.; Zhu, Y.; Kishore, R.; Losordo, D.W.  Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction.  Circulation 2006, 114(21), 2261-2270.

Rajasingh, J.; Bord, E.; Luedemann, C.; Asai, J.; Hamada, H.; Thorne, T.; Qin, G.; Goukassian, D.; Zhu, Y.; Losordo, D.W.; Kishore, R.  IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression.  FASEB J. 2006, 20(12), 2112-2114.