Northwestern University Feinberg School of Medicine
Feinberg Cardiovascular Research Institute
Asish K Ghosh, PhD

Asish K Ghosh, PhD

Research Associate Professor of Medicine (Cardiology)

Focus of Work

Bio

Major Research Interests: Molecular Basis of Organ Fibrosis: Development of Epigenetic Fibrosis Therapy.
Hyperactivity of differentiated fibroblasts causes an excessive synthesis and deposition of extracellular matrix proteins in the tissues that leads to organ fibrosis, a major cause of disease-related morbidity and mortality worldwide. Fibrosis is a common end-stage pathological symptom of a wide spectrum of injury or stress related multi-organ diseases such as hypertension-induced accelerated...[Read full text]
Major Research Interests: Molecular Basis of Organ Fibrosis: Development of Epigenetic Fibrosis Therapy.
Hyperactivity of differentiated fibroblasts causes an excessive synthesis and deposition of extracellular matrix proteins in the tissues that leads to organ fibrosis, a major cause of disease-related morbidity and mortality worldwide. Fibrosis is a common end-stage pathological symptom of a wide spectrum of injury or stress related multi-organ diseases such as hypertension-induced accelerated cardiac and renal aging, myocardial infarction, liver cirrhosis, systemic sclerosis and idiopathic pulmonary fibrosis. Epigenetics plays a key role in the development of organ fibrosis. Our research interest focuses on the role of acetyltransferase p300, a major epigenetic regulator, in TGF-beta-induced profibrogenic signal transduction and organ fibrosis. We have previously demonstrated that acetyltransferase p300 is essential for profibrogenic signal-induced matrix protein collagen synthesis. Most importantly, the levels of p300 are significantly elevated in myofibroblasts derived from resident fibroblasts or vascular endothelial cells in response to TGF-beta and different fibrotic tissues. We are interested to determine i) the molecular basis of p300 elevation in fibrotic tissues; ii) the contribution of elevated level of p300 in cardiac and renal fibrogenesis; iii) epigenetics in cardiac and renal endothelial-to-mesenchymal transition (EndMT), cellular proliferation, migration and senescence; and iv) to develop novel epigenetic therapeutic approaches targeting acetyltransferase activity of p300 to control cardiac and renal fibrosis. We are testing the therapeutic efficacy of a novel small molecule inhibitor of acetyltransferase p300 for prevention and reversal of cardiac and renal fibrosis using murine models.[Shorten text]

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Education and Certification

  • PhD: Calcutta University, India (1991)
  • Postdoctoral Fellowship: Chicago Medical School, Molecular Biology (1996)

Contact

312-503-2150

NMH/Arkes Family Pavilion Suite 600
676 N Saint Clair
Chicago IL 60611