Douglas W. Losordo, MD

Douglas W. Losordo, MD
Director, Feinberg Cardiovascular Research Institute
Director, Program in Cardiovascular Regenerative Medicine
Eileen M. Foell Professor of Heart Research
Professor of Medicine

Douglas W. Losordo, MD joined Northwestern's Feinberg School of Medicine in late 2006 as the Director of the Feinberg Cardiovascular Research Institute.

Dr. Losordo received both a BA degree and MD degree from the University of Vermont. He completed fellowships in internal medicine, cardiovascular medicine and interventional cardiology at St. Elizabeth's Hospital in Boston and training in molecular biology at Cold Spring Harbor. Dr. Losordo was on the faculty at Tufts University School of Medicine from 1989 to 2006. From 2001-2006 he served as Chief of Cardiovascular Research at St. Elizabeth’s.

Dr. Losordo is currently Associate Editor of Circulation Research and serves on the editorial boards of Circulation, Vascular Medicine, and Stem Cells, among others. His research interests focus on angiogenesis/vasculogenesis; progenitor/adult stem cells; tissue repair/regeneration; vascular biology; and the effects of estradiol on vascular tissue.

Committed to collaborative research, Dr. Losordo encourages and supports close communication among Feinberg Cardiovascular Research Institute’s faculty members, both within the Institute and with colleagues in multiple disciplines across the Northwestern campus.

To see a recent interview with Dr. Losordo, please follow the link to CardioTube.

Selected Recent Publications

Tongers, J.; Roncalli, J.G.; Losordo, D.W. Therapeutic angiogenesis for critical limb ischemia: microvascular therapies coming of age. Circulation 2008, 118(1), 9-16.

Roncalli, J.G.; Tongers, J.; Renault, M.A.; Losordo, D.W. Endothelial progenitor cells in regenerative medicine and cancer: a decade of research. Trends Biotechnol. 2008, 26(5), 276-283.

Renault, M.A.; Losordo, D.W. Therapeutic myocardial angiogenesis. Microvasc. Res. 2007, 74(2-3), 159-171.

Rajasingh, J.; Bord, E.; Hamada, H.; Lambers, E.; Qin, G.; Losordo, D.W.; Kishore, R. STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction. Circ. Res. 2007, 101(9), 910-918.

Losordo, D.W.; Schatz, R.A.; White, C.J.; Udelson, J.E.; Veereshwarayya, V.; Durgin, M.; Poh, K.K.; Weinstein, R.; Kearney, M.; Chaudhry, M.; Burg, A.; Eaton, L.; Heyd, L.; Thorne, T.; Shturman, L.; Hoffmeister, P.; Story, K.; Zak, V.; Dowling, D.; Traverse, J.H.; Olson, R.E.; Flanagan, J.; Sodano, D.; Murayama, T.; Kawamoto, A.; Kusano, K.F.; Wollins, J.; Welt, F.; Shah, P.; Soukas, P.; Asahara, T.; Henry, T.D. Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial. Circulation 2007, 115(25), 3165-3172.

Quraishi, A.; Losordo, D.W. Ischemic tissue repair by autologous bone marrow-derived stem cells: scientific basis and preclinical data. Handb. Exp. Pharmacol. 2007, 180, 167-179.

Goukassian, D.A.; Qin, G.; Dolan, C.; Murayama, T.; Silver, M.; Curry, C.; Eaton, E.; Luedemann, C.; Ma, H.; Asahara, T.; Zak, V.; Mehta, S.; Burg, A.; Thorne, T.; Kishore, R.; Losordo, D.W. Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization. Circulation 2007, 115(6), 752-762.

Kirchmair, R.; Tietz, A.B.; Panagiotou, E.; Walter, D.H.; Silver, M.; Yoon, Y.S.; Schratzberger, P.; Weber, A.; Kusano, K.; Weinberg, D.H.; Ropper, A.H.; Isner, J.M.; Losordo, D.W. Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF. Mol. Ther. 2007, 15(1), 69-75.

Hamada, H.; Kim, M.K.; Iwakura, A.; Ii, M.; Thorne, T.; Qin, G.; Asai. J.; Tsutsumi, Y.; Sekiguchi, H.; Silver, M.; Wecker, A.; Bord, E.; Zhu, Y.; Kishore, R.; Losordo, D.W. Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction. Circulation 2006, 114(21), 2261-2270.

Kawamoto, A.; Iwasaki, H.; Kusano, K.; Murayama, T.; Oyamada, A.; Silver, M.; Hulbert, C.; Gavin, M.; Hanley, A.; Ma, H.; Kearney, M.; Zak, V.; Asahara, T.; Losordo, D.W. CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cells. Circulation 2006, 114(20), 2163-2169.

Qin, G.; Kishore, R.; Dolan, C.M.; Silver, M.; Wecker, A.; Luedemann, C.N.; Thorne, T.; Hanley, A.; Curry, C.; Heyd, L.; Dinesh, D.; Kearney, M.; Martelli, F.; Murayama, T.; Goukassian, D.A.; Zhu, Y.; Losordo, D.W. Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proc. Natl. Acad. Sci. USA 2006, 103(29), 11015-11020.

Asai, J.; Takenaka, H.; Kusano, K.F.; Ii, M.; Luedemann, C.; Curry, C.; Eaton, E.; Iwakura, A.; Tsutsumi, Y.; Hamada, H.; Kishimoto, S.; Thorne, T.; Kishore, R.; Losordo, D.W. Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation 2006, 113(20), 2413-2424.

Iwakura, A.; Shastry, S.; Luedemann, C.; Hamada, H.; Kawamoto, A.; Kishore, R.; Zhu, Y.; Qin, G.; Silver, M.; Thorne, T.; Eaton, L.; Masuda, H.; Asahara, T.; Losordo, D.W. Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9. Circulation 2006, 113(12), 1605-1614.