Gangjian Qin, MD
Assistant Professor of Medicine

Ganjian Qin received an MD degree at the Tongji Medical University in China. His residency training was completed at the Union Hospital of Tongji Medical University, Department of Pediatrics (1989–91). At Union Hospital he also completed a pediatric fellowship with a specialization in neonatology (1991–92). He completed a fellowship in molecular and cellular biology at the International Centre for Genetic Engineering and Biotechnology, Trieste, Italy (1995–98). He worked as a research assistant in hematology and oncology at the University of Illinois at Chicago (1998–2001) and as senior research fellow at Caritas St. Elizabeth’s Medical Center, Tufts University School of Medicine (2001–04).

Dr Qin served on the faculty of Tongji Medical University from 1992–95 and at Tufts University School of Medicine from 2004–07.

In 2007 he was appointed assistant professor of medicine at Northwestern University's Feinberg School of Medicine and he is an investigator in the Feinberg Cardiovascular Research Institute.

His research focuses on the cardiovascular functions of the E2F family of transcription factors, with respect to ischemic angiogenesis and hypertension. Another area of interest is in adult stem cells, particularly the identification of genes and molecular pathways that are crucial for cardiac and vascular tissue repair.

Mobilized bone marrow-derived stem cells (red) incorporating into newly-formed vessels (green) in an ischemic limb.

Selected Recent Publications

Cho, H.-J.; Lee, N.; Lee, J.Y.; Choi, Y.J.; Ii, M.; Wecker, A.; Jeong, J.-O.; Curry, C.; Qin, G.; Yoon, Y.-S.. Role of host tissues for sustained humoral effects following endothelial progenitor cell transplantation into the ischemic heart.  J. Exp. Med. 2007, 204(13), 3257-3269.

Liu, D.; Lu, F.; Qin, G.; Fernandes, S.M.; Li, J.; and Davis, A.E. 3rd.  C1 Inhibitor-Mediated Protection from Sepsis. J. Immunol. 2007, 179(6), 3966-3972.

Goukassian, D.A.; Qin, G.; Dolan, C.; Murayama, T.; Silver, M.; Curry, C.; Eaton, E.; Luedemann, C.; Ma, H.; Asahara, T.; Zak, V.; Mehta, S.; Burg, A.; Thorne, T.; Kishore, R.; Losordo, D.W. Tumor Necrosis Factor-α Receptor p75 is Required in Ischemia-Induced Neovascularization. Circulation 2007, 115(6), 752-762.

Qin, G.; Kishore, R.; Dolan, C.M.; Silver, M.; Wecker, A.; Luedemann, C.N.; Thorne, T.; Hanley, A.; Curry, C.; Heyd, L.; Dinesh, D.; Kearney, M.; Martelli, F.; Murayama, T.; Goukassian, D.A.; Zhu, Y.; Losordo, D.W.  Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF.  Proc. Natl. Acad. Sci. USA 2006, 103(29), 11015-11020.

Qin, G.; Ii, M.; Silver, M.; Wecker, A.; Bord, E.; Ma, H.; Gavin, M.; Goukassian, D.A.; Yoon, Y.S.; Papayannopoulou, T.; Asahara, T.; Kearney, M.; Thorne, T.; Curry, C.; Eaton, L.; Heyd, L.; Dinesh, D.; Kishore, R.; Zhu, Y.; Losordo, D.W.  Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization.  J. Exp. Med. 2006, 203(1), 153-163.

Kishore, R.; Qin, G.; Luedemann, C.; Bord, E.; Hanley, A.; Silver, M.; Gavin, M.; Yoon, Y.S.; Goukassian, D.; Losordo, D.W.  The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A.  J. Clin. Invest. 2005, 115(7), 1785-1796.

Yoon, Y.S.; Wecker, A.; Heyd, L.; Park, J.S.; Tkebuchava, T.; Kusano, K.; Hanley, A.; Scadova, H.; Qin, G.; Cha, D.H.; Johnson, K.L.; Aikawa, R.; Asahara, T.; Losordo, D.W.  Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction.  J. Clin. Invest. 2005, 115(2), 326-338.